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מניעת לידות מוקדמות L-arginine infusion reduces preterm uterine contractions

Facchinetti F, Neri I, Genazzani AR,

L-arginine infusion reduces preterm uterine contractions

Abstract

In order to investigate the role of nitric oxide in preterm labor, 10 women presenting with preterm onset of uterine contractionswere infused with L-Arginine. In comparison to saline infusion, L-Arginine significantly reduced the number of contractions, together with an increase of both serum growth hormone and nitrates levels. These findings demonstrate that the enhancement of endogenous nitric oxide production through its physiological donor, L-Arginine, is able to transiently reduce preterm uterinespontaneous contractility.

Facchinetti F, Neri I, Genazzani AR. L-arginine infusion reduces preterm uterine contractions. J Perinat Med 1996;24:283-285.