מאמרים ומחקרים

מחקרים מוכיחים כיארגינולין משפר את מחזור הדם באופן משמעותי

חפש לפי נושא
חיפוש חופשי

שיפור תפקוד האנדוטל בכלי הדם הקורונרים

Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR Jr ,

BACKGROUND:

Coronary endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilating and vasoconstricting factors and coronary vasoconstriction in response to the endothelium-dependent vasodilator acetylcholine. Thus, the present double-blind, randomized study was designed to test the hypothesis that long-term, 6-month supplementation of L-arginine, the precursor of the endothelium-derived vasodilator NO, reverses coronary endothelial dysfunction to acetylcholine in humans with nonobstructive coronary artery disease.

METHODS AND RESULTS:

Twenty-six patients without significant coronary artery disease on coronary angiography and intravascular ultrasound were blindly randomized to either oral L-arginine or placebo, 3 g TID. Endothelium-dependent coronary blood flow reserve to acetylcholine (10(-6) to 10(-4) mol/L) was assessed at baseline and after 6 months of therapy. There was no difference between the two study groups in clinical characteristics or in the coronary blood flow in the response to acetylcholine at baseline. After 6 months, the coronary blood flow in response to acetylcholine in the subjects who were taking L-arginine increased compared with the placebo group (149 +/- 20% versus 6 +/- 9%, P < 0.05). This was associated with a decrease in plasma endothelin concentrations and an improvement in patients' symptoms scores in the L-arginine treatment group compared with the placebo group.

CONCLUSIONS:

Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations. This study proposes a role for L-arginine as a therapeutic option for patients with coronary endothelial dysfunction and nonobstructive coronary artery disease.

 

Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR J  Long-term Larginine supplementation improves small-vessel coronary endothelial function in humansCirculation. 1998;97:2123–2128